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1

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Linker Design for Antibody–Drug Conjugates

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 1.91 MB

english, 2015

2

Design of an in vivo cleavable disulfide linker in recombinant fusion proteins

Chen, Xiaoying, Bai, Yun, Zaro, Jennica, Shen, Wei-Chiang

Journal:

Year:

2010

Language:

english

File:

PDF, 573 KB

english, 2010

3

Fusion protein linkers: Property, design and functionality

Chen, Xiaoying, Zaro, Jennica L., Shen, Wei-Chiang

Journal:

Advanced Drug Delivery Reviews

Year:

2013

Language:

english

File:

PDF, 1.07 MB

english, 2013

4

Conjugation of Poly-L-lysine to Albumin and Horseradish Peroxidase: A Novel Method of Enhancing the Cellular Uptake of Proteins

Wei-Chiang Shen and Hugues J.-P. Ryser

Journal:

Proceedings of the National Academy of Sciences

Year:

1978

Language:

english

File:

PDF, 1.38 MB

english, 1978

5

Cationized Bowman-Birk Protease Inhibitor as a Targeted Cancer Chemopreventive Agent

Ekrami, Hossein, Kennedy, Ann R., Witschi, Hanspeter, Shen, Wei-Chiang

Journal:

Journal of Drug Targeting

Year:

1993

Language:

english

File:

PDF, 816 KB

english, 1993

6

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || ADCETRIS: A Regulatory Case Study of a New Generation Antibody-Drug Conjugate

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 783 KB

english, 2015

7

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 ||

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 6.42 MB

english, 2015

8

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Major ADC Companies, Current Clinical Trials, Recent Patents Issued and Patent Applications, and Cost Analysis of Drug Therapy

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 776 KB

english, 2015

9

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Bioanalytical Assay for Characterization of Antibody-Drug Conjugates (ADCs)

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 1.15 MB

english, 2015

10

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Antibody-Drug Conjugates: A Historical Review

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 694 KB

english, 2015

11

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Ado-Trastuzumab Emtansine

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

12

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Selecting an Optimal Antibody for Antibody- Drug Conjugate Therapy

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

13

[AAPS Advances in the Pharmaceutical Sciences Series] Antibody-Drug Conjugates Volume 17 || Formulation Development for Antibody-Drug Conjugates

Wang, Jeffrey, Shen, Wei-Chiang, Zaro, Jennica L.

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

14

Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures andin vivostudies in drug delivery

Zaro, Jennica L., Shen, Wei-Chiang

Journal:

Frontiers of Chemical Science and Engineering

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

15

Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery

Zhou, Li, Wang, Hsuan-Yao, Tong, Shanshan, Okamoto, Curtis T., Shen, Wei-Chiang, Zaro, Jennica L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

16

Conjugation of methotrexate to poly (L-lysine) as a potential way to overcome drug resistance

Hugues J.-P. Ryser, Wei-Chiang Shen

Journal:

Year:

1980

Language:

english

File:

PDF, 543 KB

english, 1980

17

The cellular uptake of horseradish peroxidase and its poly(lysine) conjugate by cultured fibroblasts is qualitatively similar despite a 900-fold difference in rate

Hugues J.-P. Ryser, Iain Drummond, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1982

Language:

english

File:

PDF, 1.84 MB

english, 1982

18

Altered endocytosis in a mutant of LM fibroblasts defective in cell–cell fusion

Wande Li, Hugues J.-P. Ryser, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1986

Language:

english

File:

PDF, 646 KB

english, 1986

19

Methotrexate-poly(lysine) as a selective agent for mutants of chinese hamster ovary cells defective in endocytosis

Hugues J.-P. Ryser, Richard Mandel, Asteghik Hacobian, Dr. Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1988

Language:

english

File:

PDF, 982 KB

english, 1988

20

Stable variant of LM fibroblast defective in fluid-phase but competent in receptor-mediated endocytosis

Hugues J.-P. Ryser, Wande Li, Richard Mandel, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1988

Language:

english

File:

PDF, 844 KB

english, 1988

21

Transcellular processing of disulfide-and thioether-linked peroxidase-polylysine conjugates in cultured MDCK epithelial cells

Jiansheng Wan, Stefano Persiani, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1990

Language:

english

File:

PDF, 745 KB

english, 1990

22

Isolation of variants of chinese hamster ovary cells with abnormally low levels of GSH: Decreased ability to cleave endocytosed disulfide bonds

Richard Mandel, Hugues J.-P. Ryser, Bijan Niaki, Farooq Ghani, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1991

Language:

english

File:

PDF, 775 KB

english, 1991

23

Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells

Mitchell E. Taub, Wei-Chiang Shen

Journal:

Journal of Cellular Physiology

Year:

1992

Language:

english

File:

PDF, 876 KB

english, 1992

24

Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells

Leena N. Patel, Tomomi Uchiyama, Kwang-Jin Kim, Zea Borok, Edward D. Crandall, Wei-Chiang Shen, Vincent H.L. Lee

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 258 KB

english, 2008

25

Disposition of positively charged Bowman–Birk protease inhibitor conjugates in mice: Influence of protein conjugate charge density and size on lung targeting

Hossein Ekrami, Ann R. Kennedy, Wei-Chiang Shen

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 780 KB

english, 1995

26

Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments

Byron Ballou, Jean M. Reiland, Geoffrey Levine, Rodney J. Taylor, Wei-Chiang Shen, Hughes J.-P. Ryser, Davor Solter, Thomas R. Hakala

Journal:

Journal of Surgical Oncology

Year:

1986

Language:

english

File:

PDF, 1.57 MB

english, 1986

27

Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells

Maureen P. Barnes, Wei-Chiang Shen

Journal:

International Journal of Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 614 KB

english, 2009

28

Gastric retention and stability of lipidized Bowman–Birk protease inhibitor in mice

Jeff Wang, Wei-Chiang Shen

Journal:

International Journal of Pharmaceutics

Year:

2000

Language:

english

File:

PDF, 91 KB

english, 2000

29

In vivoantitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma

Stefano Persiani, Byron Ballou, Wei-Chiang Shen, Hugues J. -P. Ryser, Jean M. Reiland, Thomas R. Hakala

Journal:

Cancer Immunology, Immunotherapy

Year:

1989

Language:

english

File:

PDF, 464 KB

english, 1989

30

Tissue localization of methotrexate-monoclonal-IgM immunoconjugates: Anti-SSEA-1 and MOPC 104E in mouse teratocarcinomas and normal tissues

Byron Ballou, Ronald Jaffe, Stefano Persiani, Wei-Chiang Shen, John J. Langone, Howard Sands, Jean M. Reilandu, Joseph Curley, Thomas R. Hakala

Journal:

Cancer Immunology, Immunotherapy

Year:

1992

Language:

english

File:

PDF, 4.54 MB

english, 1992

31

Reversible Lipidization Prolongs the Pharmacological Effect, Plasma Duration, and Liver Retention of Octreotide

Liyun Yuan, Jeff Wang, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

32

Improving the Oral Efficacy of Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Protein by Spacer Optimization

Yun Bai, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 284 KB

english, 2006

33

Cell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives

Leena N. Patel, Jennica L. Zaro, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 431 KB

english, 2007

34

Enhancement of Insulin Transport Across Primary Rat Alveolar Epithelial Cell Monolayers by Endogenous Cellular Factor(s)

Rana Bahhady, Kwang-Jin Kim, Zea Borok, Edward D. Crandall, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 303 KB

english, 2007

35

Insertion of the Designed Helical Linker Led to Increased Expression of Tf-Based Fusion Proteins

Nurmamet Amet, Hsin-Fang Lee, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 134 KB

english, 2009

36

Colorimetric determination of microgram quantities of polylysine by trypan blue precipitation

Wei-Chiang Shen, Daming Yang, Hugues J.-P. Ryser

Journal:

Analytical Biochemistry

Year:

1984

Language:

english

File:

PDF, 291 KB

english, 1984

37

A cytostatic protein isolated from the conditioned medium of mouse monocytic leukemia WEHI-3 cell cultures

Xiantang Du, Aaron Yeung, Wei-Chiang Shen

Journal:

Immunology Letters

Year:

1989

Language:

english

File:

PDF, 1.25 MB

english, 1989

38

Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans

Ying-Ku Lu, Kai-Hui Sun, Wei-Chiang Shen

Journal:

Molecular Microbiology

Year:

2005

Language:

english

File:

PDF, 529 KB

english, 2005

39

Phylogenetic study of two truffles, Tuber formosanum and Tuber furfuraceum, identified from Taiwan

Jing-Yang Huang, Hung-Tao Hu, Wei-Chiang Shen

Journal:

FEMS Microbiology Letters

Year:

2009

Language:

english

File:

PDF, 1.93 MB

english, 2009

40

Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells

Deven Shah, Wei-chiang Shen

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 210 KB

english, 1996

41

Antiproliferative Activity of Polymer-Bound, Monoamine-Coordinated Platinum Complexes Against LNCaP Human Metastatic Prostate Adenocarcinoma Cells

Wei-Chiang Shen, Karin Beloussow, Maria G. Meirim, Eberhard W. Neuse, Gregg Caldwell

Journal:

Journal of Inorganic and Organometallic Polymers and Materials

Year:

2000

Language:

english

File:

PDF, 98 KB

english, 2000

42

Antiproliferative Activity of Polyaspartamide–Ferrocene Conjugates Containing the Biofissionable Carboxamide Function in the Anchoring Links

Gregg Caldwell, Maria G. Meirim, Eberhard W. Neuse, Karin Beloussow, Wei-Chiang Shen

Journal:

Journal of Inorganic and Organometallic Polymers and Materials

Year:

2000

Language:

english

File:

PDF, 100 KB

english, 2000

43

Tyrphostin-8 Enhances Transferrin Receptor-Mediated Transcytosis in Caco-2 Cells and Increases Hypoglycemic Effect of Orally Administered Insulin-Transferrin Conjugate in Diabetic Rats

Cindy Q. Xia, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 143 KB

english, 2001

44

Structure-Activity Relationship of Reversibly Lipidized Peptides: Studies of Fatty Acid-Desmopressin Conjugates

Jeff Wang, Daphne Wu, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

45

Effects of Deoxycholate on the Transepithelial Transport of Sucrose and Horseradish Peroxidase in Filter-Grown Madin–Darby Canine Kidney (MDCK) Cells

Yi-Jing Lin, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 736 KB

1991

46

Comparison of Pharmacokinetic Parameters of a Polypeptide, the Bowman-Birk Protease Inhibitor (BBI), and Its Palmitic Acid Conjugate

Laura Honeycutt, Jeff Wang, Hossein Ekrami, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 810 KB

1996

47

Paclitaxel and Nocodazole Differentially Alter Endocytosis in Cultured Cells

Sarah F Hamm-Alvarez, Manisha Sonee, Kathleen Loran-Goss, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.98 MB

1996

48

Preparation, Purification, and Characterization of a Reversibly Lipidized Desmopressin with Potentiated Anti-Diuretic Activity

Jeff Wang, Daisy Shen, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.07 MB

1999

49

Transepithelial Transport of Tyramine Across Filter-Grown MDCK Cells via a Poly(D-lysine) Carrier

Mitchell E. Taub, Jiansheng Wan, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 1.35 MB

1994

50

Effects of Spermine-Conjugated Bowman-Birk Inhibitor (Spermine-BBI) on Carcinogenesis and Cholesterol Biosynthesis in Mice

Ann R. Kennedy, David Kritchevsky, Wei-Chiang Shen

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 55 KB

english, 2003